LTBP4 Inhibits the Proliferation and Metastasis in Melanoma by Activating Hippo-YAP Signaling

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Malignant melanoma is the deadliest of skin cancer. The present study aimed to elucidate potential key candidate genes in melanoma and its molecular mechanism. <bold>Methods: </bold>Three gene expression profile data sets (GSE46517, GSE52882 and GSE54493) were downloaded from the GEO database, which included data from melanoma tissue samples and cell lines. DEGs...

Topics

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• Bioinformatics and Genomic Networks
• Chemokine receptors and signaling
• Cutaneous Melanoma Detection and Management
• FOXO transcription factor regulation
• Melanoma and MAPK Pathways
• Skin and Cellular Biology Research
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

129396c3-fd62-577d-b2a4-69a62dc75fce

DOI

10.21203/rs.3.rs-115116/v1