Article

Continuous Infusion of the CXCR4 Antagonist Plerixafor for WHIM Syndrome

2025-04-22

Abstract excerpt

WHIM (Warts, Hypogammaglobulinemia, Infections and Myelokathexis) syndrome is an ultrarare inborn error of immunity caused by heterozygous, gain-of-function CXCR4 mutations that impede leukocyte egress from bone marrow, resulting in panleukopenia. The CXCR4 antagonist plerixafor (AMD3100, Mozobil) durably reverses panleukopenia and in most WHIM patients induces wart regression; however, its short half-life require...

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Literature Corpus work: 121a8da5-1116-5191-8825-e7e7dddcaecd
DOI: 10.1101/2025.04.19.25325865

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