Article

Endothelial PKA targets ATG16L1 to regulate angiogenesis by limiting autophagy

2019-03-12

Abstract excerpt

The cAMP-dependent protein kinase A (PKA) regulates a plethora of cellular functions in health and disease. During angiogenesis, PKA activity in endothelial cells controls the transition from sprouting to vessel maturation and limits tip cell formation independently of Notch signaling. The molecular PKA targets mediating these effects remain unknown. We report a chemical genetics screen identifying endothelial-spe...

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Literature Corpus work: 120677b2-a33f-570b-bcde-91ef106aa016
DOI: 10.1101/573683

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