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Ai-Augmented Management of Pharmacoresistant Insomnia and Restless Legs Syndrome in Park2 Parkinson’s Disease: an N-Of-1 Case Report Integrating Pharmacogenetics, Chronopharmacology, Digital Monitoring, and an Llm Co-Pilot

2026-02-13

Abstract excerpt

<title>Abstract</title> <p>We report a case of young-onset PARK2 Parkinson’s disease complicated by severe, persistent insomnia, restless legs syndrome (RLS), and REM sleep behavior disorder (RBD), refractory to multiple conventional strategies. The clinical course included features consistent with levodopa-related rebound and augmentation, culminating in a systemic crisis with near-total sleep deprivation and ni...

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Literature Corpus work
12001810-227e-5c22-86ca-e7cabbfd80c6
DOI
10.21203/rs.3.rs-8815425/v1
Open publication

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Ai-Augmented Management of Pharmacoresistant Insomnia and Restless Legs Syndrome in Park2 Parkinson’s Disease: an N-Of-1 Case Report Integrating Pharmacogenetics, Chronopharmacology, Digital Monitoring, and an Llm Co-PilotDOI 10.21203/rs.3.rs-8815425/v1
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