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A Multi-Agent AI Framework for Predicting Alzheimer’s Disease Trajectory Through Sleep-Dependent Memory Consolidation Biomarkers: A Conceptual Architecture

2026-04-09

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<title>Abstract</title> <p> <bold>Background</bold> : Alzheimer’s disease (AD) affects over 55 million people worldwide and is projected to nearly triple by 2050, yet clinical diagnosis typically occurs after substantial irreversible neuronal damage. Emerging evidence demonstrates that disruptions in sleep-dependent memory consolidation—including alterations in sleep spindle–slow oscillation coupling, rapid eye...

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Literature Corpus work: ae066749-11f3-5f0c-a647-0ec7e9f905be
DOI: 10.21203/rs.3.rs-9270054/v1

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