Article

Using regulatory genomics data to interpret the function of disease variants and prioritise genes from expression studies

2018-02-23

Abstract excerpt

The identification of therapeutic targets is a critical step in the research and developement of new drugs, with several drug discovery programmes failing because of a weak linkage between target and disease. Genome-wide association studies and large-scale gene expression experiments are providing insights into the biology of several common diseases, but the complexity of transcriptional regulation mechanisms ofte...

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Literature Corpus work: 11da39c8-60fb-51f9-b19e-f3014b4b4bda
DOI: 10.12688/f1000research.13577.2

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