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The loss of IL-31 signaling attenuates bleomycin-induced pulmonary fibrosis

2020-12-20

Abstract excerpt

Idiopathic Pulmonary Fibrosis (IPF) is a severe fibrotic lung disease characterized by excessive collagen deposition and progressive decline in lung function. Th2 T cell-derived cytokines including IL-4 and IL-13 have been shown to contribute to inflammation and fibrotic remodeling in multiple tissues. Interleukin-31 (IL-31) is a newly identified cytokine that is predominantly produced by CD4 Th2 T cells, but its...

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Literature Corpus work
10e085de-1128-500c-8bae-79c0bcc965e1
DOI
10.1101/2020.12.18.423450
Open publication

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