Article

A vitamin D-RelB/NF-κB pathway limits Chandipura virus multiplication by rewiring the homeostatic state of autoregulatory type 1 interferon-IRF7 signaling

2021-11-02

Abstract excerpt

Besides its functions in the skeletomuscular system, vitamin D also promotes protective immunity against viral pathogens. Viral sensing by mammalian cells triggers nuclear activation of RelA/NF-κB and IRF3 factors, which collaborate in mediating the early induction of antiviral type 1 interferons (T1-IFNs). Autocrine T1-IFN signaling further accumulates otherwise negligibly expressed IRF7 in virus-infected cells t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 10affcc5-0325-56f8-a9e7-603a0049af08
DOI: 10.1101/2021.11.01.466649

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A vitamin D-RelB/NF-κB pathway limits Chandipura virus multiplication by rewiring the homeostatic state of autoregulatory type 1 interferon-IRF7 signalingDOI 10.1101/2021.11.01.466649Read

Chandipura virus requires pro-survival RelA NF-κB function for its propagationSemantic proximity Read

Piscine Vitamin D Receptors Vdra/Vdrb in the Absence of Vitamin D Are Utilized by Grass Carp Reovirus for Promoting Viral ReplicationSemantic proximity Read

A Review: Highlighting the Links between Epigenetics, COVID-19 Infection, and Vitamin DSemantic proximity Read

Vitamin D-Regulated MicroRNAs: Are They Protective Factors against Dengue Virus Infection?Semantic proximity Read

Vitamin D Reprograms Non-Coding RNA Networks to Block Zika Virus in Human MacrophagesSemantic proximity Read

Vitamin D enhances antiviral responses in dengue virus-infected macrophages by modulating early-response gene expressionSemantic proximity Read

Evidence of a dysregulated Vitamin D pathway in SARS-CoV-2 infected patient’s lung cellsSemantic proximity Read

Balance between Retroviral Latency and Transcription: Based on HIV ModelSemantic proximity Read

Tretinoin, a Vitamin A derivative, exerts antiviral effects against Chikungunya virus infection through the nuclear retinoid receptor signaling pathwaysSemantic proximity Read

Vitamin D Sufficiency Reduced Risk for Morbidity and Mortality in COVID-19 PatientsSemantic proximity Read

Calcifediol boosts the efficacy of ChAdOx1 nCoV-19 (COVISHIELD) vaccine via upregulation of key genes associated with memory T cell responsesSemantic proximity Read

IFN-λ1 Displays Various Levels of Antiviral Activity In Vitro in a Select Panel of RNA VirusesSemantic proximity Read