Role of Hypertrophic Adipocytes, Collagen VI and CD38 in Fat Fibrosis of Patients with Obesity

Abstract excerpt

Fat fibrosis correlates to metabolic consequences in patients with obesity, and is due to three types of collagen: I and III (fibrillar) and VI (non-fibrillar). In this sudy the extent of fibrosis in obese patients (n 50) was significant only in visceral parenchymal fat (4.7% vs 2.5% in controls (n 15) P<0.0001) and not in subcutaneous fat. Electron microscopy, in vivo and in vitro data, suggested that obese adipo...

Topics

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• Collagen Type VI
• Extracellular Matrix
• Genes, Dominant
• Genes, Recessive
• Mice
• Molecular Targeted Therapy
• Muscular Diseases
• Mutation

Identifiers and source

Literature Corpus work

10497a0e-bc04-5b96-8b3f-088ac187b49d

DOI

10.1101/2025.10.08.681115