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Large-scale CRISPRi and transcriptomics of Staphylococcus epidermidis identify genetic factors implicated in commensal-pathogen lifestyle versatility

2021-05-20

Abstract excerpt

<title>Abstract</title> <p><italic>Staphylococcus (S.) epidermidis </italic>is a ubiquitous human commensal skin bacterium and prevalent nosocomial pathogen, but genetic factors underlying this lifestyle plasticity are incompletely understood. We developed a large-scale CRISPR interference (CRISPRi) screen complemented by transcriptional profiling (RNA-seq) across 24 conditions and piloted droplet-based CRISPRi....

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Literature Corpus work
1008efca-ae07-5c5b-a6eb-d11480c7c2ca
DOI
10.21203/rs.3.rs-484119/v1
Open publication

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Large-scale CRISPRi and transcriptomics of Staphylococcus epidermidis identify genetic factors implicated in commensal-pathogen lifestyle versatilityDOI 10.21203/rs.3.rs-484119/v1
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