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Article

Proteasomal Inhibition Triggers Viral Oncoprotein Degradation via Autophagy-Lysosomal Pathway

2019-09-23

Abstract excerpt

Epstein-Barr virus (EBV) nuclear oncoprotein EBNA3C is essential for B-cell transformation and development of several B-cell lymphomas particularly those are generated in an immuno-compromised background. EBNA3C recruits ubiquitin-proteasome machinery for deregulating multiple cellular oncoproteins and tumor suppressor proteins. Although EBNA3C is found to be ubiquitinated at its N-terminal region and interacts wi...

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Literature Corpus work
0efaf3ee-e5cf-576b-a6f6-5b82db2e2475
DOI
10.1101/780171
Open publication

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Proteasomal Inhibition Triggers Viral Oncoprotein Degradation via Autophagy-Lysosomal PathwayDOI 10.1101/780171
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