Article

Conditioned Media and Extracellular Vesicles Derived from Human Wharton's Jelly Mesenchymal Stem Cells Improve the in vitro Maturation of Immature Oocytes in Normal and PCOS Mouse Model

2025-09-04

Abstract excerpt

<title>Abstract</title> <p>Background The effects of conditioned medium (CM) and extracellular Vesicles (EVs) derived from human Wharton’s jelly mesenchymal stem cells (hWJMSCs) on in vitro maturation (IVM) of immature oocytes in both normal and polycystic ovary syndrome (PCOS)-induced mice were investigated. PCOS was induced in adult female NMRI mice by administering letrozole (90 µg/kg/day) via gavage for one w...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0edd9d40-3b24-5811-a56e-3a27e6a5f140
DOI: 10.21203/rs.3.rs-7410176/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Conditioned Media and Extracellular Vesicles Derived from Human Wharton's Jelly Mesenchymal Stem Cells Improve the in vitro Maturation of Immature Oocytes in Normal and PCOS Mouse ModelDOI 10.21203/rs.3.rs-7410176/v1Read

Improvement of oocyte in vitro maturation from mice with polycystic ovary syndrome by human mesenchymal stromal cell–conditioned mediaSemantic proximity Read

Ovarian support cell in vitro maturation (OSC-IVM) results in healthy murine live births with no evidence of reprotoxicology in a multigenerational studySemantic proximity Read

Pro-cumulin addition in a biphasic in vitro oocyte maturation system modulates human oocyte and cumulus cell transcriptomesSemantic proximity Read

HucMSC-EVs Facilitate In Vitro Development of Maternally Aged Preantral Follicles and OocytesSemantic proximity Read

In-vitro maturation of human germinal vesicle stage oocytes: role of cumulus cells and epidermal growth factor in the culture mediumSemantic proximity Read

i In vitro i strategies to enhance oocyte developmental competenceSemantic proximity Read

Exosomal Communication Between Cumulus–Oocyte Complexes and Granulosa Cells: A New Molecular Axis for Oocyte Competence in Human-Assisted ReproductionSemantic proximity Read

In vitro maturation of oocytes as a laboratory approach to polycystic ovarian syndrome ( PCOS ): From oocyte to embryoSemantic proximity Read

A proteomic signature of oocyte quality from models of varying oocyte developmental competenceSemantic proximity Read

Small-extracellular vesicles and their microRNA cargo from porcine follicular fluids: the potential association with oocyte qualitySemantic proximity Read

Mitochondrial Ca2+ Overload Leads to Mitochondrial Oxidative Stress and Delayed Meiotic Resumption in Mouse OocytesSemantic proximity Read

Quercetin-Loaded Mesenchymal Stem Cell Derived Extracellular Vesicles Enhance Ovarian Function in a Cyclophosphamide Induced Ovarian DamageSemantic proximity Read