Article

Liver microbiome composition associates with histological severity and PNPLA3 genotype in metabolic dysfunction-associated steatotic liver disease

2026-07-01

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Metabolic dysfunction-associated steatotic liver disease (MASLD) is a systemic immunometabolic disorder rapidly increasing worldwide, affecting nearly 38% of adults. Gut dysbiosis and host genetic factors, such as PNPLA3 I148M variant, modulate disease development and progression. Through the gut–liver axis, increased intestinal permeability enables microbial translocation t...

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Literature Corpus work: 0e73a625-54c7-5a83-85da-ea7cb588fe15
DOI: 10.64898/2026.06.30.735597

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