Article

<i>Theobroma cacao</i> improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia

2021-02-18

Abstract excerpt

A gain-of-function mutation in the fibroblast growth factor receptor 3 gene ( FGFR3 ) results in achondroplasia (ACH), the most frequent form of dwarfism. The constitutive activation of FGFR3 impaired bone formation and elongation and many signaling transduction pathways. Identification of new and relevant compounds targeting the FGFR3 signaling pathway is of broad importance for the treatment of ACH. Natural pla...

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Literature Corpus work: 0d4fdff8-4ace-53af-be55-8b03a929a6bb
DOI: 10.1101/2021.02.18.431801

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