Article

P422: OMIPALISIB, A DUAL PI3K/MTOR INHIBITOR, TARGETS MITOCHONDRIA AND IMPAIRS OXIDATIVE PHOSPHORYLATION IN ACUTE MYELOID LEUKEMIA

2022-06-01

Abstract excerpt

Background: Mitochondria play a central role in cell metabolism. Recent studies explored mitochondrial alterations contributing to metabolic vulnerability in myeloid leukemia cells may considered as therapeutic targets. We previously reported that omipalisib, a PI3K/mTOR dual inhibitor, could significantly inhibit the growth of myeloid leukemia cells and impair their mitochondrial respiration. However, the precise...

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Literature Corpus work: 0ceb636e-9c99-5dc2-82dc-0097be0374d5
DOI: 10.1097/01.hs9.0000844576.50131.5c

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