Article

Novel expanded ATXN10 alleles in the healthy Peruvian population: a matter of Indigenous American ethnic origin

2024-11-15

Abstract excerpt

<title>Abstract</title> <p>Spinocerebellar ataxia type 10 (SCA10) is a neurodegenerative disease predominant in Latin American individuals with Indigenous American ancestry. SCA10 is caused by an expansion of ATTCT repeat within the <italic>ATXN10</italic> gene. Healthy individuals carry 9-32 ATTCT repeats, whereas SCA10 patients carry an expansion of 280 repeats and higher. Recently, expanded alleles (>32 repeat...

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Literature Corpus work: 0b2c969f-f9a8-550e-bd38-ef58573480bb
DOI: 10.21203/rs.3.rs-5442755/v1

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