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Functional autophagy gene set signature and state classification reveal a link between autophagy induction, lysosomal activity, and poor prognosis in glioblastoma

2025-09-09

Abstract excerpt

Autophagy is an essential mechanism for maintaining cell homeostasis and, when dysregulated, is related to various pathologies. In cancer, it functions as a double-edged sword, either as a tumor suppressor or as a tumor promoter. Elevated GFP-LC3 puncta and increased levels of autophagy-related proteins, commonly interpreted as markers of high autophagic activity, are often associated with poor prognosis in tumors...

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Literature Corpus work
0abb1501-e2d4-52c6-8b5c-f9115feed25d
DOI
10.1101/2025.09.08.674856
Open publication

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Functional autophagy gene set signature and state classification reveal a link between autophagy induction, lysosomal activity, and poor prognosis in glioblastomaDOI 10.1101/2025.09.08.674856
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