Highly effective antifibrotic compound discovered as a contaminant in cefixime preparations: preliminary characterization

Abstract excerpt

There are no approved drugs for specific treatment of excessive type I collagen synthesis in organ fibrosis. The discovery that biosynthesis of type I collagen in fibrosis is regulated by binding of LARP6 to the unique sequence found in type I collagen mRNAs, the 5’ stem-loop (5’SL), prompt the search for small molecule inhibitors of LARP6 binding. A contaminant in some commercial preparations of the third-generat...

Topics

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• alpha 1-Antitrypsin Deficiency
• Disease Models, Animal
• Genotype
• Liver Cirrhosis
• Lung
• Mutation
• Peptidase Inhibition and Analysis
• Protease and Inhibitor Mechanisms

Identifiers and source

Literature Corpus work

0a0cceac-9bad-5573-b2fd-d9bee33e7764

DOI

10.1101/2025.08.28.672907