Targeting the Long Non-Coding RNA LINC00599-205 splicing by novel candidate drug ABX464 to produce the anti-inflammatory microRNA miR-124

Abstract excerpt

Many nascent long non-coding RNAs have received considerable attention in recent years because of their major regulatory roles in gene expression and signaling pathways at various levels. Indeed long non-coding RNAs undergo the same maturation steps as pre-mRNAs of proteincoding genes, but they are less efficiently spliced and polyadenylated in comparison to them. Here we focus on a specific human long non-coding...

Topics

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• Calcium Channels, L-Type
• Drug Design
• Drug Discovery
• Drug Evaluation, Preclinical
• Glucuronosyltransferase
• Neuromuscular Diseases
• Receptors, Dopamine D2
• Receptors, Opioid, mu

Identifiers and source

Literature Corpus work

097c34a5-0bd7-5a79-9f51-6d441fe96db9

DOI

10.1101/2019.12.11.871335