Article

A system biology approach identifies candidate drugs to reduce mortality in severely ill COVID-19 patients

2021-09-22

Abstract excerpt

<h4>ABSTRACT</h4> Despite the availability of highly efficacious vaccines, Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) lacks effective drug treatment which results in a high rate of mortality. To address this therapeutic shortcoming, we applied a system biology approach to the study of patients hospitalized with severe COVID. We show that, at t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0957e738-7eb8-5f6b-a201-ca756c861fb6
DOI: 10.1101/2021.09.14.21262309

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A system biology approach identifies candidate drugs to reduce mortality in severely ill COVID-19 patientsDOI 10.1101/2021.09.14.21262309Read

A systems biology approach identifies candidate drugs to reduce mortality in severely ill patients with COVID-19Semantic proximity Read

Integrative Transcriptome Analyses Empower the Anti-COVID-19 Drug ArsenalSemantic proximity Read

Integrative transcriptome analyses empower the anti-COVID-19 drug arsenalSemantic proximity Read

Integrative Transcriptome Analyses Empower the Anti-COVID-19 Drug ArsenalSemantic proximity Read

Dynamic gene expression analysis reveals distinct severity phases of immune and cellular dysregulation in COVID-19Semantic proximity Read

Rapid Identification of Druggable Targets and the Power of the Phenotype SIMulator for Effective Drug Repurposing in COVID-19Semantic proximity Read

In silico Drug Repurposing to combat COVID-19 based on Pharmacogenomics of Patient Transcriptomic DataSemantic proximity Read

A Connectivity Map-Based Drug Repurposing Study and Integrative Analysis of Transcriptomic Profiling of SARS-CoV-2 InfectionSemantic proximity Read

Transcriptomic Analysis of the Peripheral Immune Cell of SARS-CoV-2 Infected Patients for Bridging the Genotype-Phenotype Gap and Drug Prediction: A Precision Medicine ApproachSemantic proximity Read

A Transcriptome Analysis Identifies Potential Preventive and Therapeutic Approaches Towards COVID-19Semantic proximity Read

A genetically based computational drug repurposing framework for rapid identification of candidate compounds: application to COVID-19Semantic proximity Read

Computational analysis to repurpose drugs for COVID-19 based on transcriptional response of host cells to SARS-CoV-2Semantic proximity Read