Article

A Custom Global Screening Array for Integrated Familial Hypercholesterolemia Detection and Polygenic Risk Assessment in a Multi-Ethnic New Zealand Population

2026-06-24

Abstract excerpt

<h4>Background</h4> Cardiovascular disease (CVD) is the leading cause of mortality in New Zealand, with significant inequities affecting Māori and Pacific peoples. Familial hypercholesterolemia (FH) affects approximately 1 in 313 individuals globally, yet over 90% remain undiagnosed. Standard polygenic risk scores (PRS) derived from European cohorts may not be portable to diverse ancestries. We developed the Holo...

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Literature Corpus work: 09453580-83f8-5ffe-9e37-7c841d454857
DOI: 10.64898/2026.06.22.26355820

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