Article
Fifty generations of amitosis: tracing asymmetric allele segregation in polyploid cells with single-cell DNA sequencing
2021-03-30
Abstract excerpt
Amitosis is a widespread form of unbalanced nuclear division whose biomedical and evolutionary significance remain unclear. Traditionally, insights into the genetics of amitosis are acquired by assessing the rate of phenotypic assortment. The phenotypic diversification of heterozygous clones during successive cell divisions reveals the random segregation of alleles to daughter nuclei. Though powerful, this experim...
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Identifiers and source
- Literature Corpus work
- 0915a06d-32ab-5045-ae64-76919a8d68db
- DOI
- 10.1101/2021.03.29.437473