Article

A single amino acid substitution in the Borna disease virus glycoprotein enhances the infectivity titer of vesicular stomatitis virus pseudotyped virus by altering membrane fusion activity

2024-05-22

Abstract excerpt

Borna disease virus 1 (BoDV-1) causes acute fatal encephalitis in mammals, including humans. Despite its importance, research on BoDV-1 cell entry has been hindered by low viral particle production in cells and the lack of cytopathic effects. To address these issues, we developed a method to efficiently produce vesicular stomatitis virus (VSV) pseudotyped with glycoprotein (G) of the genus Orthobornavirus , inclu...

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Literature Corpus work: 086ef936-cc3a-5a6c-b001-e03e3ca00ecd
DOI: 10.1101/2024.05.22.595257

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