Article

Shuttle Peptide Delivers Base Editor RNPs to Rhesus Monkey Airway Epithelial Cells In Vivo

2023-02-17

Abstract excerpt

<title>Abstract</title> <p>Gene editing strategies for cystic fibrosis are challenged by the complex barrier properties of airway epithelia. We previously reported that the amphiphilic S10 shuttle peptide non-covalently combined with CRISPR-associated (Cas) ribonucleoprotein (RNP) enabled editing of human and mouse airway epithelial cells. Here, to improve base editor RNP delivery, we optimized S10 to derive the...

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Literature Corpus work: 077bcb52-4fbd-5e59-b36e-0b83e49e8043
DOI: 10.21203/rs.3.rs-2540755/v1

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