Article

Transcriptional networks predating cognition-associated pyramidal lineages are restructured by erythropoietin

2023-02-05

Abstract excerpt

<h4>ABSTRACT</h4> Recombinant human erythropoietin (rhEPO) has potent procognitive effects, hematopoiesis-independent, but underlying mechanisms and physiological role of brain-expressed EPO have remained obscure. Here, we provide encyclopedic transcriptional hippocampal profiling of mice treated with rhEPO. Based on ∼108,000 single nuclei, we unmask multiple pyramidal lineages with their comprehensive molecular...

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Literature Corpus work: 06e4d0c1-2e5d-5026-958d-253c595d361c
DOI: 10.1101/2023.02.04.527116

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