Article

<i>Ex vivo</i> primary liver sections recapitulate disease phenotype and therapeutic rescue for liver monogenic diseases

2023-03-24

Abstract excerpt

In academic research and the pharmaceutical industry, in vitro single cell line cultures and in vivo animal models are considered as gold standards in modelling diseases and assessing therapeutic efficacy. However, both models have limitations, with incomplete reproduction of pathophysiological characteristics and absence of 3-dimensional architecture with cell lines or the use of live animals brings ethical con...

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Literature Corpus work: 06996fec-f43d-5e85-82df-c0a9b608eab8
DOI: 10.1101/2023.03.23.533840

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