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Mechanistic Insight into the Antimicrobial Mode of Action of Usnic Acid and Its Synergy with Norfloxacin against Methicillin-Resistant Staphylococcus aureus

2024-07-29

Abstract excerpt

In this study, global response analysis was performed to explore the mechanism of action of Usnic acid and its synergy with Norfloxacin, a well-known quinolone antibiotic to which MRSA clinical isolates showed resistance (MIC, 500 µg/mL). Microdilution assay, growth kinetics, microscopic analysis, and cell-based assays consistently showed that Usnic acid possess strong anti-staphylococcal activity (MIC, 7.8 µg/ml)...

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Literature Corpus work
0682547a-f77f-59e3-810b-0137dc82334e
DOI
10.20944/preprints202407.2326.v1
Open publication

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