Article

Alzheimer’s Disease Knowledge Graph Enhances Knowledge Discovery and Disease Prediction

2024-07-05

Abstract excerpt

<h4>Background</h4> Alzheimer’s disease (AD), a progressive neurodegenerative disorder, continues to increase in prevalence without any effective treatments to date. In this context, knowledge graphs (KGs) have emerged as a pivotal tool in biomedical research, offering new perspectives on drug repurposing and biomarker discovery by analyzing intricate network structures. Our study seeks to build an AD-specific kn...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 067c61c9-f2b6-5d24-a534-e7d1e644847a
DOI: 10.1101/2024.07.03.601339

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Alzheimer’s Disease Knowledge Graph Enhances Knowledge Discovery and Disease PredictionDOI 10.1101/2024.07.03.601339Read

Graph embedding-based link prediction for literature-based discovery in Alzheimer's Disease.Semantic proximity Read

Knowledge Graph and Machine Learning Help the Research of Drugs Aimed at Neurological DiseasesSemantic proximity Read

Enriched knowledge representation in biological fields: A case study of Literature-based Discovery in Alzheimer's DiseaseSemantic proximity Read

BIND: Large-Scale Biological Interaction Network Discovery through Knowledge Graph-Driven Machine LearningSemantic proximity Read

Task-Driven Knowledge Graph Filtering Improves Prioritizing Drugs for RepurposingSemantic proximity Read

Unsupervised co-optimization of a graph neural network and a knowledge graph embedding model to prioritize causal genes for Alzheimer’s DiseaseSemantic proximity Read

PKG-LLM: A Framework for Predicting GAD and MDD Using Knowledge Graphs and Large Language Models in Cognitive NeuroscienceSemantic proximity Read

A Literature-Based Knowledge Graph Embedding Method for Identifying Drug Repurposing Opportunities in Rare DiseasesSemantic proximity Read

Repurposing Non-pharmacological Interventions for Alzheimer’s Diseases through Link Prediction on Biomedical LiteratureSemantic proximity Read

Beyond associations: A benchmark Causal Relation Extraction Dataset (CRED) of disease-causing genes, its comparative evaluation, interpretation and applicationSemantic proximity Read

ARCH: Large-scale Knowledge Graph via Aggregated Narrative Codified Health Records AnalysisSemantic proximity Read

Multi-Task Graph Neural Network For Alzheimer’s Disease Drug Repurposing Using Knowledge Graph And Multi-Level EvidenceSemantic proximity Read