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The Overexpression of AmpC is Not Required but May Contribute to Imipenem/Relebactam Non-susceptibility

2023-08-16

Abstract excerpt

In the US, carbapenem resistance in Pseudomonas aeruginosa is strongly linked to the regulation of chromosomal resistance determinants, AmpC and OprD. The β-lactamase AmpC requires overexpression and genetic modifications to be capable of inhibiting imipenem activity. The outer membrane porin OprD can be downregulated or undergo genetic modifications that strongly correlate with imipenem non-susceptibility. Co-ad...

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Literature Corpus work
065148a6-4d6b-5848-819c-7611adb25c94
DOI
10.1101/2023.08.15.553407
Open publication

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