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Insertional inactivation of oprD in clinical isolates of Pseudomonas aeruginosa leading to carbapenem resistance

9 Jun 2004

Abstract excerpt

Recently, a Texas, USA hospital isolated seven Pseudomonas aeruginosa strains displaying dual resistance to fluoroquinolones and imipenem. These isolates were resistant to the fluoroquinolones through overexpression of the MexXY efflux pump and/or QRDR mutations and resistant to imipenem through downregulation of oprD transcription. The purpose of this study was to evaluate the molecular events responsible for...

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Identifiers

PMID: 15212803
DOI: 10.1016/j.femsle.2004.05.039

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Insertional inactivation of oprD in clinical isolates of Pseudomonas aeruginosa leading to carbapenem resistancePMID 15212803Read ↗

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