Article

miR-325-3p Facilitates Tumorigenesis and Acquired Pemigatinib Resistance in Intrahepatic Cholangiocarcinoma via Targeting ADH1B through Epithelial–Mesenchymal Transition and PI3K/AKT Signaling

2026-08-20

Abstract excerpt

<title>Abstract</title> <p>Background: Intrahepatic cholangiocarcinoma (iCCA) constitutes a particularly aggressive form of primary liver cancer, characterized by a five-year overall survival rate that falls short of 10% and a scarcity of effective systemic therapeutic interventions. Although pemigatinib, an inhibitor targeting FGFR1–3, stands as the sole targeted treatment authorized by the FDA for iCCA cases in...

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Literature Corpus work: 05dfbe61-6c90-5a06-833f-f820c4f71d7e
DOI: 10.21203/rs.3.rs-10625428/v1

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