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The Mitochondrial Ubiquitin Ligase MARCHF5 Cooperates with MCL1 to Inhibit Apoptosis in KSHV-Transformed Primary Effusion Lymphoma Cell Lines

2024-09-24

Abstract excerpt

<h4>ABSTRACT</h4> Kaposi’s sarcoma-associated herpesvirus (KSHV) causes several malignancies in people with HIV including Kaposi’s sarcoma and primary effusion lymphoma (PEL). We have previously shown that PEL cell lines require myeloid cell leukemia-1 (MCL1) to inhibit apoptosis. MCL1 is an oncogene that is amplified in cancers and causes resistance to chemotherapy regimens. MCL1 is thus an attractive target for...

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Literature Corpus work
055a6009-83a0-5ede-85c6-c38fe9eaba81
DOI
10.1101/2024.09.23.614413
Open publication

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The Mitochondrial Ubiquitin Ligase MARCHF5 Cooperates with MCL1 to Inhibit Apoptosis in KSHV-Transformed Primary Effusion Lymphoma Cell LinesDOI 10.1101/2024.09.23.614413
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