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The viral interferon-regulatory factor-3 is required for the survival of KSHV-infected primary effusion lymphoma cells

22 Sept 2007

Abstract excerpt

Human herpesvirus-8 (HHV-8), also known as Kaposi sarcoma-associated herpesvirus (KSHV), is etiologically linked to primary effusion lymphoma (PEL). At least 10 KSHV-encoded proteins with potential roles in KSHV-associated neoplasia have been identified. However, with few exceptions, these putative oncogenes were analyzed in heterologous systems only using overexpression of single genes. Thus, the pathogenetic...

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PMID: 17890449
DOI: 10.1182/blood-2007-05-092288

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