Back to search

Article

Vanadium Complexes with Thioanilide Derivatives of Amino Acids: Inhibition of Human Phosphatases and Specificity in Various Cell Models of Metabolic Disturbances

2024-02-26

Abstract excerpt

In the text, the synthesis and characteristics of the novel ONS-type vanadium(V) complexes with thioanilide derivatives of amino acids are described. They have shown inhibition of human protein tyrosine phosphatases (PTP1B, LAR, SHP1 and SHP2) in the submicromolar range, as well as inhibition of non-tyrosine phosphatases (CDC25A and PPA2) similar to bis(maltolato)oxovanadium(IV)(BMOV). The ONS complexes increased...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
04bd8e1b-1779-5337-b9c5-b5ec02ef9acf
DOI
10.20944/preprints202304.0713.v3
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Vanadium Complexes with Thioanilide Derivatives of Amino Acids: Inhibition of Human Phosphatases and Specificity in Various Cell Models of Metabolic DisturbancesDOI 10.20944/preprints202304.0713.v3
Decavanadate: a journey in a search of a roleSemantic proximity
Enzyme PTP-1B Inhibition Studies by Vanadium Metal Complexes: A Kinetic ApproachSemantic proximity
Zinc and Oxo-Vanadium Complexes upon Binding to Phosphatase Enzymes: Structure, Electronics and ImplicationsSemantic proximity
Evaluation of cytotoxicity and genotoxicity of a novel oxovanadium complex with orotate.Semantic proximity
Combination of insulinomimetic agents H2O2 and vanadate enhances insulin receptor mediated tyrosine phosphorylation of IRS-1 leading to IRS-1 association with the phosphatidylinositol 3-kinase.Semantic proximity
Comparative network pharmacology of artificial sweeteners to understand Its health consequencesSemantic proximity
Cytotoxic Activity of Distinct Families of Phosphonic Acid Derivatives – A Chemocentric Approach to Assess Their Molecular ActionSemantic proximity
Evaluation of potential neuroprotective effects of Vanillin against MPP+/MPTP-induced dysregulation of dopaminergic regulatory mechanisms in SH-SY5Y cells and Parkinson's disease mice modelSemantic proximity
Select a neighboring publication to make it the new centre.