Article
Evaluation of cytotoxicity and genotoxicity of a novel oxovanadium complex with orotate.
Mutation research. Genetic toxicology and environmental mutagenesis - 1 Jan 2000
da Silva Gomes Pietra Stefany, da Silva Washington Wilson, de Cássia Gasparoti Gabriela, Payolla Filipe Boccato, de Oliveira Jonata Augusto, Barbugli Paula Aboud, Marin-Dett Freddy Humberto, Cavicchioli Maurício, Massabni Antonio Carlos, Resende Flávia Aparecida
Abstract excerpt
The development of new drugs based on metal complexes requires a detailed analysis of their biological endpoints. In this study, we report the genotoxic profile and influence on cell proliferation and death of the oxovanadium(IV) complex with orotic acid ([VO(C5H4N2O4)2], VO(oro)). Human hepatocellular carcinoma cells (HepG2) were the most sensitive tumor cells to VO(oro), which interfered with the integrity of...
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