CHIRP-Seq: FoxP2 transcriptional targets in zebra finch brain include numerous speech and language-related genes

Abstract excerpt

<title>Abstract</title> <p>Background Vocal learning is a rare, convergent trait that is fundamental to both human speech and birdsong. The Forkhead Box P2 (FoxP2) transcription factor appears necessary for both types of learned signals, as human mutations in FoxP2 result in speech deficits, and disrupting its expression in zebra finches impairs male-specific song learning. In juvenile and adult male finches, st...

Topics

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• Chromatin Immunoprecipitation
• Corpus Striatum
• Forkhead Transcription Factors
• Gene Regulatory Networks
• Neurites
• Oligonucleotide Array Sequence Analysis
• Primary Cell Culture
• Repressor Proteins

Identifiers and source

Literature Corpus work

0484b239-ce78-5c13-9be9-ebaa8da2b136

DOI

10.21203/rs.3.rs-4542378/v1