Article

Induction of neutralising antibodies against conserved rhinovirus capsid protein VP4 depends on presenting VP4 in a virus-like conformation

2024-07-02

Abstract excerpt

Infection with rhinovirus (RV) is associated with significant morbidity and hospitalisation in people with chronic lung disease. At present there is no approved RV vaccine or antiviral. There are approximately 180 RV serotypes, classified into 3 species (RVA, RVB, RVC). There is no cross-protection between serotypes because of high diversity in immunodominant antigenic sites. This makes it impractical to create a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 03f1dbf9-5519-5823-b669-bf14ccdda6da
DOI: 10.1101/2024.06.28.601138

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Induction of neutralising antibodies against conserved rhinovirus capsid protein VP4 depends on presenting VP4 in a virus-like conformationDOI 10.1101/2024.06.28.601138Read

Cross-Serotype Immunity Induced by Immunization with a Conserved Rhinovirus Capsid ProteinSemantic proximity Read

A rhinovirus vaccine evokes T cell mediated cross-reactive immunity in a preclinical model of rhinovirus infectionSemantic proximity Read

Antibodies induced with recombinant VP1 from human rhinovirus exhibit cross-neutralisationSemantic proximity Read

Phylogenetic Reconstruction and Homology Modeling Reveal Genotypic Diversity and Immune Dysregulation in Children with Rhinovirus- Associated PneumoniaSemantic proximity Read

Single-Domain Antibodies as Therapeutics for Respiratory RNA Virus InfectionsSemantic proximity Read

Human rhinovirus‐specific CD8 T cell responses target conserved and unusual epitopesSemantic proximity Read

50-valent inactivated rhinovirus vaccine is broadly immunogenic in rhesus macaquesSemantic proximity Read

The rhinovirus puzzle: Linking virus and host factors to childhood asthma.Semantic proximity Read

Chimeric rhinoviruses as tools for vaccine development and characterization of protein epitopes.Semantic proximity Read

Recent advances in understanding rhinovirus immunitySemantic proximity Read

Virus‐like particles as powerful vaccination strategy against human virusesSemantic proximity Read

Parvovirus Capsid-Antibody Complex Structures Reveal Conservation of Antigenic Epitopes Across the FamilySemantic proximity Read