Article

Combination of olaparib and savolitinib overcomes olaparib-resistance in epithelial ovarian cancer models

2023-02-14

Abstract excerpt

<h4>Background: </h4> Resistance to PARP inhibitor occurs frequently and diversely in spite of germline/somatic BRCA mutations. Receptor tyrosine kinase cMET, which is frequently overexpressed in EOC associates with PARP1 activity and cell survival pathway. We investigated whether the combination of PARP inhibitor and cMET inhibitor could overcome PARP inhibitor resistance in resistant patient-derived xenografts (...

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Literature Corpus work: 03e5077a-1ef1-5688-af0e-99a0e7f10fe3
DOI: 10.21203/rs.3.rs-2540583/v1

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