Article

Impact of Serum Sample Storage on the Stability of TRAIL, IP-10, and CRP: Implications for Biomarker Research Employing Biobanks

2025-01-28

Abstract excerpt

1. <h4>ABSTRACT</h4> Serum biobanks are a valuable resource for proteomic screening, clinical validation and tool comparison studies. Protein integrity can be impacted by sample handling from blood draw until serum separation, by serum processing and freezing, and by storage time in the freezer. Since proteins are destabilized with different dynamics, it is critical to consider each biomarker’s behavior under the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 028757b9-768e-5ff6-9c6d-929ac947096c
DOI: 10.1101/2025.01.22.25320787

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Impact of Serum Sample Storage on the Stability of TRAIL, IP-10, and CRP: Implications for Biomarker Research Employing BiobanksDOI 10.1101/2025.01.22.25320787Read

Impact of Single Freeze-Thaw Cycles on Serum Protein Stability: Implications for Clinical Biomarker Validation Using Mass SpectrometrySemantic proximity Read

Evaluating Alteration of Blood Transcriptome Affected by Storage Conditions Using RNA SequencingSemantic proximity Read

Pre-analytical processing of plasma and serum samples for combined proteome and metabolome analysisSemantic proximity Read

Biobanking of Biological Samples at Room TemperatureSemantic proximity Read

Long-term temporal stability of circulating proteins in older adultsSemantic proximity Read

Tissue is alive: New technologies are needed to address the problems of protein biomarker pre‐analytical variabilitySemantic proximity Read

Enabling global-scale nucleic acid repositories through versatile, scalable biochemical selection from room-temperature archivesSemantic proximity Read

Multiplexed measurement of protein biomarkers in high-frequency longitudinal dried blood spot (DBS) samples: characterization of inflammatory responsesSemantic proximity Read

Analysis of serum and plasma identifies differences in molecular coverage, measurement variability, and candidate biomarker selectionSemantic proximity Read

Peripheral blood mononuclear cell phenotype and function are maintained after overnight shipping of whole bloodSemantic proximity Read

Multiplexed triage of candidate biomarkers in plasma using internal standard triggered-parallel reaction monitoring mass spectrometrySemantic proximity Read

Peripheral blood mononuclear cell phenotype and function are maintained after overnight shipping of whole blood.Semantic proximity Read