Article

Introducing Novel Molecular-based Method for Quantification of Homologous Recombination Efficiency

2021-01-19

Abstract excerpt

<h4>Background</h4> Homologous recombination (HR) pathway is a DNA double-stranded breaks repair pathway well-known for its high level of accuracy. Low HR pathway efficiency clinically known as homologous recombination deficiency (HRD) was identified in some cancers such as breast and ovarian cancers and studies have reported the sensitivity of HRD cancer cells to DNA repair inhibitors such as Olaparib. However,...

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Literature Corpus work: 020f1ab0-63ed-5aa7-bcb6-b658542f99df
DOI: 10.1101/2021.01.17.427032

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