Article

Structural patterns and transcriptional effects of integrated Epstein-Barr virus revealed by long-read sequencing and RNA-sequencing in Nasopharyngeal Carcinoma

2025-02-17

Abstract excerpt

Integration of Epstein–Barr virus (EBV) DNA into the human genome is a critical event in nasopharyngeal carcinogenesis. Here, we comprehensively characterize large-scale virus-human integration events in four EBV-positive nasopharyngeal carcinoma (NPC) cell lines and tumors using Nanopore long-read sequencing technology. We identified four distinct integration types, with Type I being particularly notable, charact...

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Literature Corpus work: 018d2a06-2d5c-5b4c-a44e-c2c51440f9c9
DOI: 10.1101/2025.02.15.638273

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Structural patterns and transcriptional effects of integrated Epstein-Barr virus revealed by long-read sequencing and RNA-sequencing in Nasopharyngeal CarcinomaDOI 10.1101/2025.02.15.638273Read

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