Article

Linkage analysis coupled with exome sequencing identified defects in gene ‘X’ causing premature ovarian insufficiency

2014-04-01

Abstract excerpt

Background Premature ovarian insufficiency (POI) is defined as a primary ovarian defect characterized by absent menarche (primary amenorrhea) or premature depletion of ovarian follicles before the age of 40 (secondary amenorrhea) with hypergonadotropism and hypoestrogenism. POI results in infertility and lifelong steroid deficiency, and is potentially associated with accelerated health risks such as cardiovascular...

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Literature Corpus work: 01861c4a-f11f-599a-8a7d-ea5cad499773
DOI: 10.1186/1471-2164-15-s2-p6

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