Article

Sp1-Induced Upregulation of LBX2-AS1 Aggravates The Progression of Glioblastoma By Targeting The miR-491-5p/LIF Axis

2021-03-01

Abstract excerpt

<h4>Background: </h4> Mounting evidences have shown the importance of lncRNAs in tumorigenesis and cancer progression. LBX2-AS1 is an oncogenic lncRNA that has been found abnormally expressed in gastric cancer and lung cancer samples. Nevertheless, the biological function of LBX2-AS1 in glioblastoma (GBM) and potential molecular mechanism are largely unclear. <h4>Methods: </h4>: Relative levels of LBX2-AS1 in GBM...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 011fe8eb-121a-5f15-b063-c11324afa821
DOI: 10.21203/rs.3.rs-242079/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sp1-Induced Upregulation of LBX2-AS1 Aggravates The Progression of Glioblastoma By Targeting The miR-491-5p/LIF AxisDOI 10.21203/rs.3.rs-242079/v1Read

LBX2-AS1 Promotes Ovarian Cancer Progression by Facilitating E2F2 Gene Expression via MIR-455-5P and MIR-491-5P SpongingSemantic proximity Read

Long noncoding RNA LPP-AS2 promotes glioma tumorigenesis via miR-7-5p/EGFR/PI3K/AKT/c-MYC feedback loopSemantic proximity Read

Integrative Bioinformatics and Experimental Investigation Introduces OBI1-AS1 as a Key LncRNA in the Progression of Low-grade Glioma to GlioblastomaSemantic proximity Read

PAXIP1-AS2 is a Promising Target for Glioma Progression and TreatmentSemantic proximity Read

Current Research Progress of the Role of LncRNA LEF1-AS1 in a Variety of TumorsSemantic proximity Read

Identification of PDLIM1 as a glioblastoma stem cell marker driving tumorigenesis and chemoresistanceSemantic proximity Read

Long noncoding RNA LBX2-AS1-modulated miR-4766-5p regulates gastric cancer development through targeting CXCL5Semantic proximity Read

LncRNA SBF2-AS1 Promotes Malignant Phenotypes and Radioresistance of Glioblastoma Cells by Impairing miR-338-3p-targeted MAP4K3 InhibitionSemantic proximity Read

Analysis of the EGFR Amplification and CDKN2A Deletion Regulated Transcriptomic Signatures Reveals the Prognostic Significance of SPATS2L in Patients With GliomaSemantic proximity Read

CSRP2 is involved in immune regulation and drug sensitivity in glioma cells by the LEF1- AS1/miR-128-3p/CSRP2 axisSemantic proximity Read

ELF1 upregulates MEIS1 to accelerate proliferation, migration and invasion of glioma cells through the GFI1/FBW7 axisSemantic proximity Read

Lnc GNG12-AS1 knockdown suppresses glioma progression through the AKT/GSK-3β/β-catenin pathwaySemantic proximity Read