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Spectrometric and computational studies of the binding of HIV-1 integrase inhibitors to viral DNA extremities

2019-07-01

Abstract excerpt

Three Integrase (IN) strand transfer inhibitors are in intensive clinical use, raltegravir, elvitegravir anddolutegravir. However, the onset of IN resistance mutations limits their therapeutic efficiency. As put forth earlier, the drug affinity for the intasome could be improved by targeting preferentially the retroviralnucleobases, which are little, if at all, mutation-prone. We report experimental results of ani...

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Literature Corpus work
00873062-6db8-5fad-9252-362eaed32e2d
DOI
10.7287/peerj.preprints.27833v1
Open publication

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Spectrometric and computational studies of the binding of HIV-1 integrase inhibitors to viral DNA extremitiesDOI 10.7287/peerj.preprints.27833v1
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