Article

Dopaminergic Degeneration and GBA Mutation Status Predict Prior–Sensory Arbitration Disruption in Parkinson's Disease: A Multimodal Computational Framework

2026-09-01

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Parkinson's disease (PD) hallucinations may arise from disrupted arbitration between prior expectations and sensory evidence, but this has not been tested using a computational framework in large clinical datasets with biomarker validation. <bold>Methods:</bold> Using the Parkinson’s Progression Markers Initiative (PPMI) dataset (5,066 subjects, 19,397 HVLT...

Identifiers and source

Literature Corpus work: 007cc8ec-aafc-5973-bcb1-9e546be1ea29
DOI: 10.21203/rs.3.rs-10864931/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

Dopaminergic Degeneration and GBA Mutation Status Predict Prior–Sensory Arbitration Disruption in Parkinson's Disease: A Multimodal Computational FrameworkDOI 10.21203/rs.3.rs-10864931/v1Read

Compensatory hallucinogenesis across three neuropsychiatric disorders: A Bayesian accountSemantic proximity Read

Changes in dynamic transitions between integrated and segregated states underlie visual hallucinations in Parkinson’s diseaseSemantic proximity Read

Parkinson’s disease impairs cortical sensori-motor decision-making cascadesSemantic proximity Read

GABAergic regulation of action-outcome priors in conditions associated with frontotemporal degenerationSemantic proximity Read

Inferring Cognitive State Underlying Conflict Choices in Verbal Stroop Task Using Heterogeneous Input Discriminative-Generative Decoder ModelSemantic proximity Read

An explainable attention-based multimodal MRI framework for Parkinson’s disease classification: a pilot feasibility and internal validation studySemantic proximity Read

Signal discrimination in the psychotic phenotype: increased sensory precision and reduced decision threshold associated with psychotic-like experiences.Semantic proximity Read

Refining Mechanistic Models of Hallucinations for Enhanced TranslatabilitySemantic proximity Read

Cognitive Phenotyping of Parkinson's Disease Patients Via Digital Analysis of Spoken Word Properties.Semantic proximity Read

Conditioned hallucinations and prior hyper-precision are state-sensitive markers of hallucination susceptibilitySemantic proximity Read

Revealing hidden knowledge in amnestic miceSemantic proximity Read

Multitarget brain implants enable generalized decoding of Parkinson’s disease symptoms from chronic home recordingsSemantic proximity Read