Article

GABAergic regulation of action-outcome priors in conditions associated with frontotemporal degeneration

2025-10-24

Abstract excerpt

<h4>Rationale</h4> Apathy is a common symptom in many neurological and psychiatric conditions, associated with poor prognosis and increased caregiver burden. There are currently no proven treatments, in part due to a lack of mechanistic understanding. We have proposed a novel framework for apathy, based on the failure of active inference due to imprecise priors on the outcome of actions. The loss of precision on...

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Literature Corpus work: b3dbc8cf-c290-5f66-bbe8-56b2e5d527f2
DOI: 10.1101/2025.10.22.25338552

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