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Predominance of neuronal mRNAs in individual Alzheimer's disease senile plaques

1 Feb 1999

Abstract excerpt

The sequestration of RNA in Alzheimer's disease (AD) senile plaques (SPs) and the production of intraneuronal amyloid-beta peptides (Abeta) prompted analysis of the mRNA profile in single immunocytochemically identified SPs in sections of AD hippocampus. By using amplified RNA expression profiling, polymerase chain reaction, and in situ hybridization, we assessed the presence and abundance of 51 mRNAs that encode...

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PMID: 9989619
DOI: 10.1002/1531-8249(199902)45:2<174::aid-ana7>3.0.co;2-e

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