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Article

Identification of transthyretin variants by sequential proteomic and genomic analysis.

Clinical chemistry - 1 Sept 2004

Bergen H Robert, Zeldenrust Steven R, Butz Malinda L, Snow Denise S, Dyck Peter J, Dyck P James B, Klein Christopher J, O'Brien John F, Thibodeau Stephen N, Muddiman David C

Abstract excerpt

BACKGROUND: Transthyretin-associated hereditary amyloidosis (ATTR) is an inherited disease in which variants in the primary structure of transthyretin (TTR; prealbumin) lead to the extracellular polymerization of insoluble protein fibrils, causing organ failure and ultimately death when major org...

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Source

Identifiers

PMID: 15217993
DOI: 10.1373/clinchem.2004.033266

Genes

TTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15217993-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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