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Article

An on-line assay for clinical detection of amyloidogenic transthyretin variants directly from serum.

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis - 1 Sept 2003

Bergen H Robert, Zeldenrust Steven R, Naylor Stephen

Abstract excerpt

We report here for the first time the on-line analysis of transthyretin genetic variants by mass spectral analysis. The use of mass spectrometry to analyze immunoprecipitated transthyretin has been previously described. However, the on-line analysis of TTR directly from serum reported here will allow for a fully automated high throughput analysis. Mutations in the plasma transport protein TTR are readily observed...

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Share to Amyloid Neuropathies, Familial
Share to TTR gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single-Stranded Conformational

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Share to Precipitin Tests

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Share to Spectrometry, Mass, Electrospray Ionization

Source

Identifiers

PMID: 14640032
DOI: 10.3109/13506120308999000

Genes

TTR
FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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