Thymidine phosphorylase is angiogenic and promotes tumor growth.

doi:10.1073/pnas.92.4.998

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Thymidine phosphorylase is angiogenic and promotes tumor growth.

Proceedings of the National Academy of Sciences of the United States of America - 14 Feb 1995

Moghaddam A, Zhang H T, Fan T P, Hu D E, Lees V C, Turley H, Fox S B, Gatter K C, Harris A L, Bicknell R

Abstract excerpt

Platelet-derived endothelial cell growth factor was previously identified as the sole angiogenic activity present in platelets; it is now known to be thymidine phosphorylase (TP). The effect of TP on [methyl-3H]thymidine uptake does not arise from de novo DNA synthesis and the molecule is not a growth factor. Despite this, TP is strongly angiogenic in a rat sponge and freeze-injured skin graft model. Neutralizing...

Topics

Animals
Breast Neoplasms
Cattle
Cell Division
Cells, Cultured
Chemotaxis
Endothelium, Vascular
Female
Humans
Male
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred BALB C

Mutation

Neovascularization, Pathologic

Rats

Rats, Wistar

Substrate Specificity

Thymidine Phosphorylase

Source

Open in PubMed Open full text

Identifiers

PMID: 7532308
DOI: 10.1073/pnas.92.4.998
PMCID: PMC42624

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7532308-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Thymidine phosphorylase is angiogenic and promotes tumor growth.PMID 7532308Read ↗

Angiogenesis - still a worthwhile target for breast cancer therapy?Semantic proximity Read ↗

Are tumours angiogenesis-dependent?Semantic proximity Read ↗

Neo-angiogenesis in locally advanced squamous cell head and neck cancer correlates with thymidine phosphorylase expression and p53 nuclear oncoprotein accumulation.Semantic proximity Read ↗

Expression of uridine and thymidine phosphorylase genes in human breast carcinomaSemantic proximity Read ↗

Switch to the angiogenic phenotype during tumorigenesis.Semantic proximity Read ↗

VEGF-B: a thing of beautySemantic proximity Read ↗

Tumor angiogenesis: molecular pathology, therapeutic targeting, and imaging.Semantic proximity Read ↗

New molecular targets in canine hemangiosarcoma-Comparative review and future of the precision medicine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.